TRAIL and its receptors

TRAIL and its receptors Cell death

More than 20 years ago, phage λ geneticists identified certain mutations, termed Chi (χ), which increase the frequency of recombination in their vicinity (reviewed in [1]). A large body of experiments in phage λ and Escherichia coli established a number of properties of χ-dependent stimulation of recombination (Figure 1). The effect occurs on linear molecules, requiring a specific orientation b...

Increased Expression of TRAIL and Its Receptors on Peripheral T-Cells in Type 1 Diabetic Patients

Background: Type-I diabetes is an autoimmune inflammatory disease in which pancreatic ß-cells are selectively destroyed by infiltrating cells. TNF-related apoptosis-inducing ligand (TRAIL) is a type-II membrane protein of the TNF superfamily which is expressed in different tissues, including pancreas and lymphocytes. In humans, TRAIL interacts with four membrane receptors. TRAIL-R1 and TRAIL-R2...

TRAIL & TRAIL Receptors

Osteoclast apoptosis: Role of TRAIL and its receptors

Control of osteoclast (OC) apoptosis has been recognized as a critical regulatory factor in bone remodelling, and alteration in OC death and/or survival has been shown to contribute to the pathogenesis of osteoporosis or malignant osteolysis. TNF-related apoptosis-inducing ligand (TRAIL) has received considerable attention as a molecule showing the unique property to induce apoptosis in a varie...

increased expression of trail and its receptors on peripheral t-cells in type 1 diabetic patients

background: type-i diabetes is an autoimmune inflammatory disease in which pancreatic ß-cells are selectively destroyed by infiltrating cells. tnf-related apoptosis-inducing ligand (trail) is a type-ii membrane protein of the tnf superfamily which is expressed in different tissues, including pancreas and lymphocytes. in humans, trail interacts with four membrane receptors. trail-r1 and trail-r2...